Search results for "Global brain atrophy"

showing 4 items of 4 documents

Association Between Atrophy of the Caudate Nuclei, Global Brain Atrophy, Cerebral Small Vessel Disease and Mild Parkinsonian Signs in Neurologically …

2017

Background: Mild Parkinsonian signs (MPS) are commonly seen in aging, and have been related to cerebral Small Vessel Diseases (SVD) with no univocal results. Objective: The aim of this study was to investigate the cross-sectional relation between MPS and White Matter Hyperintensities (WMH), lacunes, caudate atrophy, and global cerebral atrophy in a large cohort of Neurologically and Cognitively Healthy (NCH) aging individuals. Method: 1,219 NCH individuals were included in the analysis, and underwent standard brain MRI. The items of the motor section of the Unified Parkinson’s Disease Rating Scale were used to evaluate tremor, rigidity, bradykinesia, and gait/balance/axial dysfunction. Cau…

Male0301 basic medicinemedicine.medical_specialtyNeurologyNeuropsychological TestsCohort Studies03 medical and health sciencesLateral ventricles0302 clinical medicineAtrophyInternal medicineGlobal brain atrophyBasal gangliaHumansMedicineCognitive declineAgedUltrasonographyAged 80 and overCerebral atrophybusiness.industryHeartParkinson DiseaseMiddle AgedMental Status and Dementia Testsmedicine.diseaseMagnetic Resonance ImagingHyperintensityCross-Sectional Studies030104 developmental biologyNeurologyCerebral Small Vessel DiseasesCardiologyFemaleNeurology (clinical)AtrophyCaudate Nucleusbusiness030217 neurology & neurosurgeryCurrent Alzheimer Research
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Apoe genotypes and brain imaging classes in normal cognition, mild cognitive impairment, and alzheimer’s disease: A longitudinal study

2020

Objective: To evaluate in 419 stroke-free cognitively normal subjects (CN) aged 45-82 years covering during a long prospective study (11.54 ± 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (V) and brain atrophy (A) aggregated as following: V−/A−, V−/A+, V+/A−, V+/A+; 2) the relationship of these imaging classes with individual apolipoprotein E (APOE) genotypes; 3) the risk of progression to Alzheimer Disease (AD) of the individual APOE genotypes. Methods: Participants underwent one baseline (t0), and 4 clinical and neuropsychological assessments (t1,t2,t3, and t4). Brain MRI was performed in all subjects at t0, t2, t3 and t4.. White matter hyp…

MaleApolipoprotein Emedicine.medical_specialtyGenotypeApolipoprotein E4NeuroimagingNeuropsychological TestsAPOE genotypes Brain imaging classes Caudate atrophy Global cerebral atrophy Lacunes White matter hyperintensities Aged Aged 80 and over Alzheimer Disease Apolipoprotein E4 Apolipoproteins E Brain Case-Control Studies Cognitive Dysfunction Disease Progression Female Genotype Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Neuroimaging Neuropsychological Tests Risk Factorsbrain imaging classesApolipoproteins EAtrophyNeuroimagingAlzheimer DiseaseRisk FactorsInternal medicineGlobal brain atrophymedicineHumansDementiaCognitive DysfunctionLongitudinal Studiescaudate atrophyAgedglobal cerebral atrophyAged 80 and overAPOE genotypesbusiness.industryNeuropsychologyBrainMiddle Agedwhite matter hyperintensitiesmedicine.diseaseMagnetic Resonance ImagingHyperintensityNeurologyCase-Control StudiesDisease ProgressionCardiologyFemaleNeurology (clinical)Alzheimer's diseasebusiness
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Nociceptive Primitive Reflexes in Neurologically and Cognitively Healthy Aging Subjects

2019

ABSTRACT:Background:To assess the prevalence of three nociceptive primitive reflexes (nPR), i.e., glabellar tap, snout reflex, and palmomental reflex, in neurologically and cognitively healthy (NCH) aging subjects.Objective:To investigate whether nPR are cross-sectionally associated with white matter hyperintensities (WMH), lacunes, atrophy of the caudate nuclei, and global brain atrophy.Methods:A total of 1246 NCH subjects aged 45–91 years were included in the study and underwent standard brain MRI. Atrophy of the caudate nuclei and global brain atrophy were assessed through the bicaudate ratio (BCr) and lateral ventricles to brain ratio (LVBr), respectively. WMH were assessed through visu…

MalePrimitive reflexesmedicine.medical_specialtyCaudate atrophyLacuneNeuropsychological Testsbehavioral disciplines and activitiesPalmomental reflexHealthy Aging03 medical and health sciencesLateral ventriclesNociceptive primitive reflexesCognition0302 clinical medicineAtrophyInternal medicineSnout reflexGlobal brain atrophyActivities of Daily LivingWhite matter hyperintensitiesLacunesmedicineHumansCognitive DysfunctionCognitive declineAgedPain Measurement030304 developmental biologyHealthy aging subjectsAged 80 and over0303 health sciencesGlobal cerebral atrophybusiness.industryHealthy aging subjectBrainNociceptive primitive reflexeGeneral MedicineMiddle Agedmedicine.diseaseHyperintensityNeurologyCardiologyFemaleNeurology (clinical)business030217 neurology & neurosurgeryCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
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2015

Age is known to affect prefrontal brain structure and executive functioning in healthy older adults, patients with neurodegenerative conditions and TBI. Yet, no studies appear to have systematically investigated the effect of age on cognitive performance in patients with focal lesions. We investigated the effect of age on the cognitive performance of a large sample of tumour and stroke patients with focal unilateral, frontal (n=68), or non-frontal lesions (n=45) and healthy controls (n=52). We retrospectively reviewed their cross sectional cognitive and imaging data. In our frontal patients, age significantly predicted the magnitude of their impairment on two executive tests (Raven's Advanc…

medicine.medical_specialtyCognitive NeuroscienceExperimental and Cognitive PsychologyCognitionAudiologyExecutive functionsmedicine.diseasebehavioral disciplines and activitiesMiddle ageBehavioral NeuroscienceFrontal lobeGlobal brain atrophymedicineEffects of sleep deprivation on cognitive performance10. No inequalityPsychologyStrokeNeuroscienceStroop effectNeuropsychologia
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